Schwartzman stunned Nadal 6-2, 7-5 two weeks ago in the Italian capital.
The pair have not played for their country since the Cafeteros' penalty shootout defeat to Chile in the quarterfinals of last year's Copa America in Brazil.
"This was to say the least, one of my most difficult races. The altitude took a toll on me and it simply took away my breath. I just can't remember much of the race. I am happy to win in such conditions in my personal best time. I just say it was a solid performance and I am happy to wrap up my season with a win. I will take two weeks break before starting my winter preparations," said Awuah.
Julian Draxler, Idrissa Gueye and Kylian Mbappe added another three in the second half while Angers pulled one back in the 52nd minute.
Things got worse for Ole Gunnar Solskjaer's team as Anthony Martial was sent off for lashing out at Erik Lamela, and Harry Kane and Son made it 4-1 before halftime.
The win, which came as the 35th from 36 matches this season, also ties him with Rafael Nadal for a record 14th Roland Garros quarterfinals appearance.
Mikel Oyarzabal's penalty after a slightly harsh handball decision opened the scoring in the 29th minute and Real Sociedad had the game completely under control before goals from Mikel Merino and Portu in the 78th and 81st minutes assured the three points.
Those to have been ruled out of the matches include forwards Juan Carlos Arce, Gilbert Alvarez and Victor Abrego, midfielders Erwin Saavedra and Leonel Justiniano, and defenders Adrian Jusino, Luis Haquin and Diego Bejarano.
The 26-year-old Kenyan was far behind her world record of 2:14:04 that she set in Chicago last year, but met no challenge after 30 kilometers.
The match will be Iran's first game at the national level under the leadership of Dragan Skocic.
Their Canadian forward Christophe Lalancette completed his hat-trick in the final stretch to guide his team to a respected victory and the first place in the rankings, 4-5.